Research
- 1:Proteolytic Systems
  - 1.1:Neurodegenerative Diseases
  - 1.2:Proteasomes in Infections
  - 1.3:Proteasomal subtypes/Proteasomes in CNS
  - 1.4:Peptide Synthesis
  - 1.5:Mass spectrometry
  - 1.6:MHC class I Epitope Generation
- 2:Regulation of the Ubiquitin-Proteasome-System
- 3:Lipoxygenase Research
- 4:Computational Systems Biochemistry
- 5:Cell adhesion-mediated signal transduction

Laboratory Proteolytic Systems

Many physiological and pathophysiological cellular processes are regulated by the degradation of proteins and depend on the molecular interplay between different proteases and proteolytic systems. An important role thereby plays the Ubiquitin-Proteasome-System (UPS), as well as aminopeptidases of the cytoplasm and endoplasmatic reticulum. Our research is focused on the investigation of the role of these proteases and proteolytic systems in the immune response against viral infections and in tumorigenesis as well as in the development of different neurogenerative diseases.

Laboratory leader

Prof. Dr. rer. nat. P.-M. Kloetzel

Scientific Director CC2, laboratory leader Proteolytic Systems

Charité - Universitätsmedizin Berlin

CVK: Campus Virchow-Klinikum

CC 2: Basic Sciences (Year 1)

Institute of Biochemistry

Postal address:

Oudenarder Str. 16

13347 Berlin

t: +49 30 450 528 071

f: +49 30 450 528 921

Scientists

Addresses
Dr. rer. nat. Isabel Bochmann \| t: +49 30 450 528 099
Prof. Dr. rer. nat. Burkhardt Dahlmann \| t: +49 30 450 528 309
Dr. rer. nat. Frédéric Ebstein \| t: +49 30 450 528 288/ -328
Dr. rer. nat. Petra Henklein \| t: +49 30 450 528 030/ -009
Dr. rer. nat. Katharina Janek \| t: +49 30 450 528 318/ -099
Dr. rer. nat. Ulrike Kuckelkorn \| t: +49 30 450 528 186
Dr. rer. nat. Michele Mishto \| t: +49 30 450 528 288
Dr. rer. nat. Barbara Reimann \| t: +49 30 450 528 315
Dipl.-Biol. Karin Schmidt \| t: +49 30 450 528 006/ -308
Dr. rer. nat. Michael Seeger \| t: +49 30 450 528 186
Dr. Sabrina Urban \| t: +49 30 450 528 186

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PhD Students

Addresses
Richard Golnik \| t: +49 30 450 528 199
M. Sc. Biologie Felicia Kirschner \| t: +49 30 450 528 328/ -308
M. Sc. Dorota Respondek \| t: +49 30 450 528 199
Dipl.-Biol. Carolin Schächterle \| t: +49 30 450 528 328/ -199
Dipl.-Ing. Biotechnol. Friederike Schröter \| t: n. n.

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Techn. Assistants

Addresses
Barbara Brecht-Jachan \| t: +49 30 450 528 030/ -009
Christiane Kilian \| t: +49 30 450 528 328
Alexander Kloß \| t: +49 30 450 528 328/ -308
staatl. gepr. Biotechniker Agathe Niewienda \| t: +49 30 450 528 318/ -170/ -415

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