Laboratory cardiac infection biology and immunology
The overall objective of our research includes the study of cellular processes that are responsible for the controlled regulation of inflammation in heart muscle diseases. Our group is interested in the importance of the myocardial cell as a central point of an immune response, for example, during infection with pathogens.
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Fields of interest
We examine the significance of a regulation of the cellular protein equilibrium by the ubiquitin-proteasome system and by the ubiquitin-like modification ISG15 in various pathological conditions in the heart muscle. These regulatory principles are examined in particular at the interface between innate and adaptive immunity for their relevance to translational issues.
- Myocarditis / Inflammatory cardiomyopathy
- Post-translational Modification with ISG15
- Proteostasis / Ubiquitin-Proteasome System
- Cardiotropic enteroviruses