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Ein Stapel medizinischer Bücher.

Publications of the Lab Cell Adhesion mediated Signal Transduction

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Dommisch H, Stolte KN, Jager J, Vogel K, Müller R, Hedtrich S, Unbehauen M, Haag R, Danker K.:
Characterization of an ester-based core-multishell (CMS) nanocarrier for the topical application at the oral mucosa.
Clin Oral Investig. 2021 Oct;25(10):5795-5805. doi: 10.1007/s00784-021-03884-x. Epub 2021 Apr 5.
PMID: 33821321


Parczyk J, Ruhnau J, Pelz C, Schilling M, Wu H, Piaskowski NN, Eickholt B, Kühn H, Danker K, Klein A.:
Dichloroacetate and PX-478 exhibit strong synergistic effects in a various number of cancer cell lines.
BMC Cancer. 2021 Apr 30;21(1):481. doi: 10.1186/s12885-021-08186-9.
PMID: 33931028 Free PMC article.


Stolte KN, Pelz C, Yapto CV, Raguse JD, Dommisch H, Danker K:
IL-1β strengthens the physical barrier in gingival epithelial cells.
Tissue Barriers. 2020 Jul 2;8(3):1804249. doi: 10.1080/21688370.2020.1804249. Epub 2020 Aug 23.PMID: 32835592

Ruhnau J, Parczyk J, Danker K, Eickholt B, Klein A:
Synergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to screen for synergism.
BMC Cancer. 2020 Jul 2;20(1):617. doi: 10.1186/s12885-020-07062-2.PMID: 32615946 


Gildenhard M, Rono EK, Diarra A, Boissière A, Bascunan P, Carrillo-Bustamante P, Camara D, Krüger H, Mariko M, Mariko R, Mireji P, Nsango SE, Pompon J, Reis Y, Rono MK, Seda PB, Thailayil J, Traorè A, Yapto CV, Awono-Ambene P, Dabiré RK, Diabaté A, Masiga D, Catteruccia F, Morlais I, Diallo M, Sangare D, Levashina EA:
Mosquito microevolution drives Plasmodium falciparum dynamics.
Nat Microbiol. 2019 Jun;4(6):941-947. doi: 10.1038/s41564-019-0414-9. Epub 2019 Mar 25.

Standfuß C, Parczyk J, Ruhnau J, Klein A:
Genome reorganization in different cancer types: detection of cancer specific breakpoint regions.
Mol Cytogenet. 2019 Jun 20;12:25. doi: 10.1186/s13039-019-0435-3. eCollection 2019. PMID: 31249626

Semmler L, Reiter-Brennan C, Klein A:
BRCA1 and Breast Cancer: a Review of the Underlying Mechanisms Resulting in the Tissue-Specific Tumorigenesis in Mutation Carriers.
J Breast Cancer. 2019 Jan 22;22(1):1-14. doi: 10.4048/jbc.2019.22.e6. eCollection 2019 Mar. Review. PMID: 30941229


Reiter-Brennan C, Semmler L, Klein A:
The effects of 2-hydroxyglutarate on the tumorigenesis of gliomas.
Contemp Oncol (Pozn). 2018;22(4):215-222. doi: 10.5114/wo.2018.82642. Epub 2018 Dec 31. Review. PMID: 30783384

Labus J, Wöltje K., Stolte KN, Häckel S, Kim KS, Hildmann A, Danker K:
IL-1β promotes transendothelial migration of PBMCs by upregulation of the FN/α5β1 signalling pathway in immortalised human brain microvascular endothelial cells.
Exp Cell Res, in press (Oct. 2018). doi: 10.1016/j.yexcr.2018.10.002. [Epub ahead of print]

Pelz C, Häckel S, Semini G, Schrötter S, Bintig W, Stricker S, Mrawietz G, Klein A, Lucka L, Shmanai V, Eickholt B, Hildmann A, Danker K:
Inositol-C2-PAF acts as a biological response modifier and antagonizes cancer-relevant processes in mammary carcinoma cells.
Cell Oncol (Dordr). 2018 Jul 25. doi: 10.1007/s13402-018-0387-3. PMID: 30047091

Jager J, Obst K, Lohan SB, Viktorov J, Staufenbiel S, Renz H, Unbehauen M, Haag R, Hedtrich S, Teutloff C, Meinke MC, Danker K*, Dommisch H*:
Characterization of hyperbranched core-multishell nanocarriers as an innovative drug delivery system for the application at the oral mucosa.
J Periodont Res. Doi: 10.1111/jre.12487 (* shared authorship). PMID: 28898420


Hildmann A, Kairaliyeva T, Danker K, Shmanai V, Fainerman,VB, Miller R:
Adsorption characteristics of the alkyl phospholipid Inositol-C2-PAF at the solution/air interface.
Colloids and Surfaces A: Physicochemical and Engineering Aspects. 532, 578-582. doi:10.1016/j.colsurfa.2017.03.028.


Hussain M, Bork K, Gnanapragassam VS, Bennmann D, Jacobs K, Navarette-Santos A, Hofmann B, Simm A, Danker K, Horstkorte R:
Novel insights in the dysfunction of human blood-brain barrier after glycation.
Mech Aging Develop. 155:48-54. PMID: 26975648


Hildmann A, Danker K:
Modified phospholipids: from detergents towards small molecular response modifiers.
Eur J Lipid Sci Tech. 116(9):1108-1113.

Labus J, Häckel S, Lucka L, Danker K:
Interleukin-1β induces an inflammatory response and the breakdown of the endothelial cell layer in an improved human THBMEC-based in vitro blood-brain barrier model.
J Neurosci Meth. 228:35-45. PMID: 24631939

Semini G, Hildmann A, von Haefen C, Danker K:
Glycosidated Phospholipids - a promising group of anti-tumour lipids.
Anticancer Agents Med Chem 14(4): 607-617. PMID: 24628240 

Semini G, Hildmann A, Klein A, Lucka L, Schön M, Schön MP, Shmanai V, Danker K:
Inositol-C2-PAF down-regulates components of the antigen presentation machinery in a 2D-model of epidermal inflammation.
Biochem Pharmacol 87(3): 477-488. PMID: 24291779

Forkel S, Schön M, Hildmann A, Claßen A, John SM, Danker K, Schön MP:
Inositoylated Platelet Activating Factor (Ino-C2-PAF) modulates dynamic lymphocyte-endothelial cell interactions and alleviates psoriasis-like skin inflammation in two complementary mouse models.
J Invest Dermatol. 134(10):2510-20. PMID: 24714204

Klein A, Pospisil H:
Gene expression profiling of pancreatic cancer reveals a significant deregulation of the TGF-β pathway and the discovery of genes for prognosis.
Global Journal of Human Genetics & Gene Therapy. 2014 March Volume 2, No. 1:30-39. DOI: 


Gottschalk B, Klein A:
Restoration of wild-type p53 in drug-resistant mouse breast cancer cells leads to differential gene expression, but is not sufficient to overcome the malignant phenotype.
Mol Cell Biochem. 2013 Jul;379(1-2):213-27. PMID: 23564067

Römer AM, Lühr I, Klein A, Friedl A, Sebens S, Rösel F, Arnold N, Strauss A, Jonat W, Bauer M:
Normal mammary fibroblasts induce reversion of the malignant phenotype in human primary breast cancer.
Anticancer Res. 2013 Apr;33(4):1525-36. PMID: 23564794


Standfuß C, Pospisil H, Klein A:
SNP Microarray analyses reveal copy number alterations and progressive genome reorganization during tumor development in SVT/t driven mice breast cancer.
BMC Cancer. 2012 Aug 31;12(1):380. PMID: 22935085

Knauss S, Klein A:
From aneuploidy to cancer: the evolution of a new species?
J Biosci. 2012 Jun;37(2):211-20.

Hirsch B, Grünbaum M, Wagner F, Bi Y, Lucka L, Du MQ, Stein H, Dürkop H:
A novel A20 (TNFAIP3) antibody (Ber-A20) can be used to detect unmutated A20 by immunohistology.
Histopathology. 60(6B):E19-27. doi: 10.1111/j.1365-2559.2012.04181.x. PMID: 22393903


von Haefen C, Wendt J, Belka C, Radetzki S, Reutter W,. Daniel PT, Danker K:
Synthetic glycosidated phospholipids induce apoptosis through activation of FADD, caspase-8 and the mitochondrial death pathway.
Apoptosis, 16:636-651. PMID: 21437721

Semini G, Klein A, Danker K:
Impact of alkylphospholipids on the gene expression profile of HaCaT cells.
Pharmacogenet Genom, 21:375-387. PMID: 21681147

Semini G, Hildmann A, Reissig HU, Reutter W, Danker K:
The novel synthetic ether lipid Inositol-C2-PAF inhibits phosphorylation of the tyrosine kinases Src and FAK independent of integrin activation in transformed skin cells.
Biochem Pharmacol, 15:985-995. PMID: 21320472

Bednorz NL, Brill B, Klein A, Gäbel K, Groner B:
Tracking the Activation of Stat5 through the Expression of an Inducible Reporter Gene in a Transgenic Mouse Line.
Endocrinology. 2011 May;152(5):1935-47. PMID: 21427222

Möller H, Böhrsch V, Lucka L, Hackenberger CP, Hinderlich S:
Efficient metabolic oligosaccharide engineering of glycoproteins by UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) knock-down.
Mol Biosyst. 2011 Jul;7(7):2245-51. PMID: 21584309


Danker K, Reutter W, Semini G:
Glycosidated phospholipids: uncoupling of signalling pathways at the plasma membrane (review).
Brit J Pharmacol, 160:36-47. PMID: 20331609

Klein A, Li N, Nicholson JM, McCormack AA, Graessmann A, Duesberg P:
Transgenic oncogenes induce oncogene-independent cancers with individual karyotypes and phenotypes. Cancer Genet Cytogenet. 2010 Jul 15;200(2):79-99. PMID: 20620590

Weidemann W, Klukas C, Klein A, Simm A, Schreiber F, Horstkorte R:
Lessons from GNE-deficient embryonic stem cells: sialic acid biosynthesis is involved in proliferation and gene expression.
Glycobiology. 2010 Jan;20(1):107-17. Epub 2009 Sep 30. PMID: 19797319

2005 - 2009


Muñoz M, Heimesaat MM, Danker K, Struck D, Lohmann U, Bereswill S, Fischer A, Dunay IR, Wolk K, Loddenkemper C, Krell HW, Libert C, Lund LR, Frey O, Hoelscher C, Bulfone-Paus S, Iwakura Y, Ghilardi N, Ouyang W, Kamradt T, Sabat R, Liesenfeld O:
Interleukin- 23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloprotease-2 and interleukin-22 but independent of interleukin 17.
J Exp Med, 206(13):3047-59.

Patsos G, Hebbe-Viton V, Robbe-Masselot C, Masselot D, Martin RS, Greenwood R, Paraskeva C, Klein A, Graessmann M, Michalski JC, Gallagher T, Corfield A:
O-glycan inhibitors generate aryl-glycans induce apoptosis and lead to growth inhibition in colorectal cancer cell lines.
Glycobiology. 2009 Apr;19(4):382-98. PMID: 19122213

Klein A, Olendrowitz C, Schmutzler R, Hampl J, Schlag PM, Maass N, Arnold N, Wessel R, Ramser J, Meindl A, Scherneck S, Seitz S:
Identification of brain- and bone-specific breast cancer metastasis genes.
Cancer Lett. 2009 Apr 18;276(2):212-20. PMID: 19114293


Loufrani L, Bocquet A, Dumont O, Danker K, Louis H, Lacolley P, Henrion D:
Key role of the a1b1 integrin in the activation of PI3Kinase-Akt by flow (shear stress) in resistence arteries.
Am J Physiol-Heart Circ Physiol. 294: 1906-1913. PMID: 18245559

Slevogt H, Zabel S, Opitz B, Hocke A, Eitel J, N'guessan PD, Lucka L, Riesbeck K, Zimmermann W, Zweigner J, Temmesfeld-Wollbrueck B, Suttorp N, Singer BB:
CEACAM1 inhibits Toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells.
Nat Immunol. 2008 Nov;9(11):1270-8. doi: 10.1038/ni.1661. Epub 2008 Oct 5. PMID: 18836450

Kannicht C, Grunow D, Lucka L.:
Enzymatic sequence analysis of N-glycans by exoglycosidase cleavage and mass spectrometry--detection of Lewis X structures.
Methods Mol Biol. 2008;446:255-66. doi: 10.1007/978-1-60327-084-7_18. PMID: 18373263


Smerling C, Tang K, Hofmann W, Danker K:
Role of the a1 Integrin Cytoplasmic Tail in the Formation of Focal Adhesion Complexes and Actin Organization and in the Control of Cell Migration.
Exp. Cell Res. 313: 3153-3165. PMID: 17632102

Patsos G, Robbe-Masselot C, Klein A, Hebbe-Viton V, Martin RS, Masselot D, Graessmann M, Paraskeva C, Gallagher T, Corfield A:
O-glycan regulation of apoptosis and proliferation in colorectal cancer cell lines.
Biochem Soc Trans. 2007 Nov;35(Pt 5):1372-4. PMID: 17956354

Klein A, Wessel R, Graessmann M, Jürgens M, Petersen I, Schmutzler R, Niederacher R, Arnold N, Meindl A, Scherneck S, Seitz S and Graessmann A:
Comparison of gene expression data from human and mouse breast cancers: Identification of a conserved breast tumor gene set.
Int J Cancer. 2007 Aug 1;121(3):683-8. PMID: 17410534

Graessmann M, Berg B, Fuchs B, Klein A and Graessmann A:
Chemotherapy resistance of mouse WAP-SVT/t breast cancer cells is mediated by osteopontin, inhibiting apoptosis down-stream of caspase-3.
Oncogene. 2007 May 3;26(20):2840-50. PMID: 17160024

Klaile E, Müller MM, Kannicht C, Otto W, Singer BB, Reutter W, Obrink B, Lucka L:
The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38.
J Biol Chem. 2007 Sep 7;282(36):26629-40. Epub 2007 Jul 9. PMID: 17623671

Ghaderi D, Strauss HM, Reinke S, Cirak S, Reutter W, Lucka L, Hinderlich S:
Evidence for dynamic interplay of different oligomeric states of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase by biophysical methods.
J Mol Biol. 2007 Jun 8;369(3):746-58. Epub 2007 Mar 21. PMID: 17448495

Assaf C, Hirsch B, Wagner F, Lucka L, Grünbaum M, Gellrich S, Lukowsky A, Sterry W, Stein H, Dürkop H:
Differential expression of TRAF1 aids in the distinction of cutaneous CD30-positive lymphoproliferations.
J Invest Dermatol. 2007 Aug;127(8):1898-904. Epub 2007 Mar 29. PMID: 17392826


Mutz D, Weise C, Wenzel HM, Hofmann W, Horstkorte R, Danker K:
Integrin α3β1 forms a complex with phosphatase PP1 and I1PP2A/lanp.
J Neurosci. Res. 8: 1759-70. PMID: 17016859

Fischer A, Müller D, Zimmermann-Kordmann M, Kleuser B, Mickeleit M, Laabs S, Löwe W, Cantagrel F, Reutter W, Danker K:
The ether lipid, Inositol-C2-PAF, is a potent inhibitor of cell proliferation in HaCaT cells.
ChemBioChem, 7: 441-449. PMID: 16453359

Wessel R, Foos V, Aspelmeier A, Jurgens M, Graessmann A and Klein A:
CorrXpression--identification of significant groups of genes and experiments by means of correspondence analysis and ratio analysis.
In Silico Biol. 2006;6(1-2):61-70. PMID: 16789914

Penner J, Mantey LR, Elgavish S, Ghaderi D, Cirak S, Berger M, Krause S, Lucka L, Voit T, Mitrani-Rosenbaum S, Hinderlich S:
Influence of UDP-GlcNAc 2-epimerase/ManNAc kinase mutant proteins on hereditary inclusion body myopathy.
Biochemistry. 2006 Mar 7;45(9):2968-77. PMID: 16503651


Mechai N, Wenzel M, Koch M, Lucka L, Horstkorte R, Reutter W and Danker K:
The cytoplasmic tail of the a3 integrin subunit promotes neurite outgrowth in PC12 cells.
J Neurosci Res, 82: 753-761.

Bartolmäs T, Heyn T, Mickeleit M, Fischer A, Reutter W, Danker K:
Glucosamine-Glycerophospholipids activate cell-matrix adhesion and migration.
J Med Chem, 48: 6750-6755. PMID: 16220990

Lombardi Borgia S, Regehly M, Sivaramakrishnan R, Mehnert W, Korting HC, Danker K, Röder B, Kramer KD, Schäfer-Korting M:
Lipid Nanoparticles for Topical Application to the Skin: Investigation of a loaded Fluorescent Dye.
J Contr Release, 110: 151-63. PMID: 16297487

Klein A, Guhl E, Zollinger R, Tzeng YJ, Wessel R, Hummel M, Graessmann M and Graessmann A:
Gene expression profiling: cell cycle deregulation and aneuploidy do not cause breast cancer formation in WAP-SVT/t transgenic animals.
J Mol Med. 2005 May;83(5):362-76. PMID: 15662539

Klaile E, Müller MM, Kannicht C, Singer BB, Lucka L:
CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration.
J Cell Sci. 2005 Dec 1;118(Pt 23):5513-24. Epub 2005 Nov 15. PMID: 16291724

Singer BB, Klaile E, Scheffrahn I, Müller MM, Kammerer R, Reutter W, Obrink B, Lucka L:
CEACAM1 (CD66a) mediates delay of spontaneous and Fas ligand-induced apoptosis in granulocytes.
Eur J Immunol. 2005 Jun;35(6):1949-59. PMID: 15909305

Müller MM, Singer BB, Klaile E, Obrink B, Lucka L:
Transmembrane CEACAM1 affects integrin-dependent signaling and regulates extracellular matrix protein-specific morphology and migration of endothelial cells.
Blood. 2005 May 15;105(10):3925-34. Epub 2005 Feb 1. Erratum in: Blood. 2005 Jul 15;106(2):407. PMID: 15687237