
Kloetzel Lab: Proteolytic Systems
Being part of the anti-viral and anti-tumor immune response the ubiquitin-proteasome system plays a central role in the generation of epitopes or their precursor peptides, the latter requiring trimming by the aminopeptidases ERAP1/2. These peptides bind to MHC class I molecules and are transported to the cell surface where they are presented for recognition by cytotoxic T-lymphocytes. In addition to the classical epitopes proteasomes also generate spliced epitopes which are the results of the ligation of two proteasomal cleavage products.
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Secretary
Daniela Höcke
Secretary Prof. Kloetzel,
Research Organisation
t: +49 30 450 528 142
f: +49 30 450 528 921
Principal Investigator
Management Laboratory Proteolytic SystemsCharité – Universitätsmedizin Berlin