Meta menu:

From here, you can access the Emergencies page, Contact Us page, Accessibility Settings, Language Selection, and Search page.

Open Menu
Nahaufnahme mehrerer Probenröhrchen, die auf einem Tisch liegen. Im Hintergrund ist unscharf der Schriftzug "Charité" auf einem Formular erkennbar.

Kloetzel Lab: Proteolytic Systems

Being part of the anti-viral and anti-tumor immune response the ubiquitin-proteasome system plays a central role in the generation of epitopes or their precursor peptides, the latter requiring trimming by the aminopeptidases ERAP1/2. These peptides bind to MHC class I molecules and are transported to the cell surface where they are presented for recognition by cytotoxic T-lymphocytes. In addition to the classical epitopes proteasomes also generate spliced epitopes which are the results of the ligation of two proteasomal cleavage products.


You are here:

Main focus of the ongoing research is the analysis of the processing of tumor-specific epitopes which are the result of a somatic mutation as well as the investigation of the aminopeptidase ERAP1 in the context of tumor therapy by adoptive T-cell transfer.

Secretary

Daniela Höcke
Secretary Prof. Kloetzel,
Research Organisation

t: +49 30 450 528 142
f: +49 30 450 528 921

Principal Investigator

Prof. Dr. rer. nat. Peter-Michael Kloetzel

Management Laboratory Proteolytic SystemsCharité – Universitätsmedizin Berlin

Postal address:Charitéplatz 110117 Berlin

Campus / internal address:Virchowweg 6

CCM, Virchowweg 6

Scientists