Eickholt Lab: Signaling mechanisms in brain development and disease

A fundamental question in neuroscience concerns the mechanisms by which the complexity and precision of connections between cells in the nervous system is achieved. At the cellular level, this process requires the navigation of axonal processes to their appropriate target cells, the fomation of synaptic contacts with postsynaptic partners and the assembly of functional synapses, specialized structures that allow the fast transmission of information.

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Research seeks

chicken
PI3K and synapses-1

Within these areas, our research seeks:

(1) to dissect signalling mechanisms that control the dynamic reorganisation of the cytoskeleton within the growth cone and at the synapse;

(2) to understand how different members of the Semaphorin family of axon guidance molecules effect neuronal circuit formation;

(3) investigate the temporal and spatial aspect of neuronal signalling by the use of high-resolution live cell imaging.

We believe that our research into the signalling mechanisms that control the dynamic reorganisation of the cytoskeleton within the growth cone and at the synapse has - in general - potentially direct implications for developing and validating pharmacological therapeutics for the treatment of varius neurological disorders.

The Eickholt Lab is part of NeuroCure Cluster of Excellence at the CharitéUniversitätsmedizin Berlin.

Sluggish growth cone

Video: Sluggish growth cone: Neuronal growth cones are transient structures at the tips of neurites. They sample the environment for guidance information and navigate neurites to the correct synaptic targets.

Principal Investigator

Prof. Dr. Britta Eickholt

Director of Institute, Director of Centrum and Manager of Laboratory Signaling mechanisms in brain development and diseaseCharitéUniversitätsmedizin Berlin

Postal address:Charitéplatz 110117 Berlin

Campus / internal address:Virchowweg 6

Directions / Location map

PhD Students

Annika Brosig
Annika Brosig

PhD Student

Juliane Schiweck
Juliane Schiweck

PhD Student

Joachim Fuchs
Joachim Fuchs

PhD Student