Laboratory Signaling mechanisms in brain development and disease

A fundamental question in neuroscience concerns the mechanisms by which the complexity and precision of connections between cells in the nervous system is achieved. At the cellular level, this process requires the navigation of axonal processes to their appropriate target cells, the fomation of synaptic contacts with postsynaptic partners and the assembly of functional synapses, specialized structures that allow the fast transmission of information.

  • chicken
  • PI3K and synapses-1

Within these areas, our research seeks:
(1) to dissect signalling mechanisms that control the dynamic reorganisation of the cytoskeleton within the growth cone and at the synapse; (2) to understand how different members of the Semaphorin family of axon guidance molecules effect neuronal circuit formation; (3) investigate the temporal and spatial aspect of neuronal signalling by the use of high-resolution live cell imaging.

We believe that our research into the signalling mechanisms that control the dynamic reorganisation of the cytoskeleton within the growth cone and at the synapse has - in general - potentially direct implications for developing and validating pharmacological therapeutics for the treatment of varius neurological disorders.

 

 

The Eickholt Lab is part of NeuroCure Cluster of Excellence at the Charité - Universitätsmedizin Berlin.

Sluggish growth cone

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Neuronal growth cones are transient structures at the tips of neurites. They sample the environment for guidance information and navigate neurites to the correct synaptic targets

Principal Investigator

Prof. Dr. Britta Eickholt

EickholtB

Management Laboratory Signaling mechanisms in brain development and disease

Charité - Universitätsmedizin Berlin

CCM: Campus Charité Mitte

Charité Center Basic Sciences CC 2

Institute of Biochemistry

Postal address:

Charitéplatz 1

10117 Berlin

Internal address:

Virchowweg 6

t: +49 30 450 539 121

f: +49 30 450 528 921

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Links:

Scientists

Dr. Stefanie Gögel | t: +49 30 450 539 116
Dr. Paloma Goni-Oliver | t: +49 30 450 513 279
Dr. Patricia Kreis | t: +49 30 450 539 116
Dr. rer. nat. Julia Ledderose | t: +49 30 450 513 279
Dr. rer. nat. Till Mack | t: +49 30 450 539 116
Dr. rer. nat. Kai Murk | t: +49 30 450 539 116
Dr. rer. nat. Mayur Vadhvani | t: +49 30 450 513 279

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PhD Students

Claudia Bentz | t: +49 30 450 539 116
Annika Brosig | t: +49 30 450 513 279
Eugenia Rojas-Puente | t: +49 30 450 513 279
Sandra Schrötter | t: +49 30 450 513 279

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Techn. Assistants

Beate Diemar | t: +49 30 450 528 147
Kristin Lehmann | t: +49 30 450 528 147
Kerstin Schlawe | t: +49 30 450 528 147

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Alumni

Aminul Ahmed
Neil Chadborn
Katharina Cosker
Sonja Ferl
Rita Hendricusdottir
Rachel Jackson
Louise Kay
Dr. phil. George Leondaritis | t: +49 30 450 539 116
Tomas Perez
Michiel van Diepen

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