Eickholt Lab: Signaling mechanisms in brain development and disease
A fundamental question in neuroscience concerns the mechanisms by which the complexity and precision of connections between cells in the nervous system is achieved. At the cellular level, this process requires the navigation of axonal processes to their appropriate target cells, the fomation of synaptic contacts with postsynaptic partners and the assembly of functional synapses, specialized structures that allow the fast transmission of information.
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- analyze the signaling mechanisms that control the dynamic reorganization of the cytoskeleton in the growth cone and at the synapse;
- to investigate the temporal and spatial aspect of neural signal transmission through high-resolution live cell imaging. Our detailed analyzes of the signal transmission mechanisms that control the dynamic reorganization of the cytoskeleton in the growth cone and at the synapse are important for the development and validation of pharmacological therapeutics for the treatment of various neurological disorders.