Publikationen des Labors Biochemie und Systembiologie des Stoffwechsels

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2020

Gossmann TI, Ralser M. 
Marmota marmota.
Trends Genet. 2020 Feb 3. pii: S0168-9525(20)30019-6. doi: 10.1016/j.tig.2020.01.006

Demichev V, Messner CB, Vernardis SI, Lilley KS, Ralser M. 
DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput.
Nat Methods. 2020 Jan;17(1):41-44. doi: 10.1038/s41592-019-0638-x. Epub 2019 Nov 25.

2019

Campbell K, Correia-Melo C, Ralser M. 
Self-Establishing Communities: A Yeast Model to Study the Physiological Impact of Metabolic Cooperation in Eukaryotic Cells.
Methods Mol Biol. 2019;2049:263-282. doi: 10.1007/978-1-4939-9736-7_16.

Olin-Sandoval V, Yu JSL, Miller-Fleming L, Alam MT, Kamrad S, Correia-Melo C, Haas R, Segal J, Peña Navarro DA, Herrera-Dominguez L, Méndez-Lucio O, Vowinckel J, Mülleder M, Ralser M. 
Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism.
Nature. 2019 Aug;572(7768):249-253. doi: 10.1038/s41586-019-1442-6. Epub 2019 Jul 31.

Segal J, Mülleder M, Krüger A, Adler T, Scholze-Wittler M, Becker L, Calzada-Wack J, Garrett L, Hölter SM, Rathkolb B, Rozman J, Racz I, Fischer R, Busch DH, Neff F, Klingenspor M, Klopstock T, Grüning NM, Michel S, Lukaszewska-McGreal B, Voigt I, Hartmann L, Timmermann B, Lehrach H, Wolf E, Wurst W, Gailus-Durner V, Fuchs H, H de Angelis M, Schrewe H, Yuneva M, Ralser M. 
Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase deficiency.
J Inherit Metab Dis. 2019 Sep;42(5):839-849. doi: 10.1002/jimd.12105. Epub 2019 Jun 11.

Gossmann TI, Shanmugasundram A, Börno S, Duvaux L, Lemaire C, Kuhl H, Klages S, Roberts LD, Schade S, Gostner JM, Hildebrand F, Vowinckel J, Bichet C, Mülleder M, Calvani E, Zelezniak A, Griffin JL, Bork P, Allaine D, Cohas A, Welch JJ, Timmermann B, Ralser M. 
Ice-Age Climate Adaptations Trap the Alpine Marmot in a State of Low Genetic Diversity.
Curr Biol. 2019 May 20;29(10):1712-1720.e7. doi: 10.1016/j.cub.2019.04.020. Epub 2019 May 9.

Kaminski Strauss S, Schirman D, Jona G, Brooks AN, Kunjapur AM, Nguyen Ba AN, Flint A, Solt A, Mershin A, Dixit A, Yona AH, Csörgő B, Busby BP, Hennig BP, Pál C, Schraivogel D, Schultz D, Wernick DG, Agashe D, Levi D, Zabezhinsky D, Russ D, Sass E, Tamar E, Herz E, Levy ED, Church GM, Yelin I, Nachman I, Gerst JE, Georgeson JM, Adamala KP, Steinmetz LM, Rübsam M, Ralser M, Klutstein M, Desai MM, Walunjkar N, Yin N, Aharon Hefetz N, Jakimo N, Snitser O, Adini O, Kumar P, Soo Hoo Smith R, Zeidan R, Hazan R, Rak R, Kishony R, Johnson S, Nouriel S, Vonesch SC, Foster S, Dagan T, Wein T, Karydis T, Wannier TM, Stiles T, Olin-Sandoval V, Mueller WF, Bar-On YM, Dahan O, Pilpel Y. 
Evolthon: A community endeavor to evolve lab evolution.
PLoS Biol. 2019 Mar 29;17(3):e3000182. doi: 10.1371/journal.pbio.3000182. eCollection 2019 Mar.

Keller MA, Kampjut D, Harrison SA, Driscoll PC, Ralser M. 
Reply to 'Do sulfate radicals really enable a non-enzymatic Krebs cycle precursor?'
Nat Ecol Evol. 2019 Feb;3(2):139-140. doi: 10.1038/s41559-018-0792-z.

Jensen LR, Garrett L, Hölter SM, Rathkolb B, Rácz I, Adler T, Prehn C, Hans W, Rozman J, Becker L, Aguilar-Pimentel JA, Puk O, Moreth K, Dopatka M, Walther DJ, von Bohlen Und Halbach V, Rath M, Delatycki M, Bert B, Fink H, Blümlein K, Ralser M, Van Dijck A, Kooy F, Stark Z, Müller S, Scherthan H, Gecz J, Wurst W, Wolf E, Zimmer A, Klingenspor M, Graw J, Klopstock T, Busch D, Adamski J, Fuchs H, Gailus-Durner V, de Angelis MH, von Bohlen Und Halbach O, Ropers HH, Kuss AW. 
A mouse model for intellectual disability caused by mutations in the X-linked 2'‑O‑methyltransferase Ftsj1 gene.
Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2083-2093. doi: 10.1016/j.bbadis.2018.12.011. Epub 2018 Dec 14

 

 

 

2018

Stynen B, Abd-Rabbo D, Kowarzyk J, Miller-Fleming L, Aulakh SK, Garneau P, Ralser M, Michnick SW.
Changes of Cell Biochemical States Are Revealed in Protein Homomeric Complex Dynamics.
Cell. 2018 Nov 15;175(5):1418-1429.e9. doi: 10.1016/j.cell.2018.09.050. Epub 2018 Oct 25.

Patil KR, Ralser M.
Freeing Yeast from Alcohol Addiction (Just) to Make (It) Fat Instead.
Cell. 2018 Sep 6;174(6):1342-1344. doi: 10.1016/j.cell.2018.08.024.

Ralser M.
An appeal to magic? The discovery of a non-enzymatic metabolism and its role in the origins of life.
Biochem J. 2018 Aug 30;475(16):2577-2592. doi: 10.1042/BCJ20160866. Review.

Zelezniak A, Vowinckel J, Capuano F, Messner CB, Demichev V, Polowsky N, Mülleder M, Kamrad S, Klaus B, Keller MA, Ralser M:
Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase Knockouts.
Cell Syst. 2018 Sep 26;7(3):269-283.e6. PMID: 30195436

Vowinckel, J., Zelezniak, A., Bruderer, R., Mülleder, M., Reiter, L., Ralser, M.: 
Cost-effective generation of precise label-free quantitative proteomes in high-throughput by microLC and data-independent acquisition.
Sci Rep. 2018;8(1):4346. PMID: 29531254

Campbell K, Herrera-Dominguez L, Correia-Melo C, Zelezniak A, Ralser M: 
Biochemical principles enabling metabolic cooperativity and phenotypic heterogeneity at the single cell Level.
Current Opinion in Systems Biology 2018, 8:97-108.

2017

Keller MA, Kampjut D, Harrison SA, Ralser M:
Sulfate radicals enable a non-enzymatic Krebs cycle precursor.
Nature Ecol and Evol. 2017. PMID: 28584880

Kit-Yi Leung, Yun Jin Pai, Qiuying Chen, Chloe Santos, Enrica Calvani, Sonia Sudiwala, Dawn Savery, Markus Ralser, Steven S. Gross, Andrew J. Copp, Nicholas D.E. Greene:
Partitioning of one-carbon units in folate and methionine metabolism is essential for neural tube closure.
Cell Reports. 2017 Nov 14;21(7):1795-1808. PMID: 29141214

Olga Ponomarova, Natalia Gabrielli, Daniel Sevin, Michael Mülleder, Katharina Zirngibl, Katsiaryna Bulyha, Sergej Andrejev, Eleni Kafkia, Athanasios Typas, Uwe Sauer, Markus Ralser & Kiran Raosaheb Patil.
Yeast creates a niche for symbiotic lactic acid bacteria through nitrogen overflow.
Cell Systems, 2017, 25;5(4):345-357.e6. PMID: 28964698

Haas R, Zelezniak A, Iacovacci J, Karmad S, Townsend S, Ralser M:
Designing and interpreting 'multi-omic' experiments that may Change our understanding of biology.
Current Opinion in Systems Biology 2017 Dec.

Gemayel R, Yang Y, Dzialo M, Kominek J, Vowinckel J, Saels V, van Huffel L, van der Zande E, Ralser M:
Variable Repeats in the Eukaryotic Polyubiquitin Gene UBI4 Modulate Proteostasis and Stress Survival.
Nature Communications 2017

Keller MA, Driscoll PC, Messner C, Ralser M:
H-NMR as implemented in several origin of life studies artificially implies the Absence of metabolism-like non-enzymatic reactions by being signal-suppressed.
Wellcome Open Res. 2017 

Alam MT, Olin-Sandoval V, Stincone A, Keller MA, Zelezniak A, Luisi BF, Ralser M:
The self-inhibitory nature of metabolic Networks and its alleviation through compartmentalization.
Nature Communications 2017

Messner CB, Driscoll PC, Piedrafita G, de Volder MFL, Ralser M:
Nonenzymatic gluconeogenesis-like formation of fructose 1,6-bisphosphate in ice.
Proc Natl Acad Sci USA 2017. PMID: 28652321

Moraru A, Cakan-Agdogan G, Strassburger K, Males M, Mueller S, Jabs M, Muelleder M, Frejno M, Braeckman BP, Ralser M, Teleman AA:
THADA Regulates the Organismal Balance between Energy Storage and Heat Production.
Dev Cell 207. PMID: 28535378

Weber RJM, Lawson TN, Salek RM, Ebbels TMD, Glen RC, Goodacre R, Griffin JL, Haug K, Koulman A, Moreno P, Ralser M, Steinbeck C, Dunn WB, Viant MR:
Computational tools and workflows in metabolomics: An international survey highlights the opportunity for harmonisation through Galaxy.
Metabolomics. 2017;13(2):12.

Caudy AA, Mülleder M, Ralser M:
Metabolomics in Yeast.
Cold Spring Harb Protoc. 2017 Sep 1. PMID: 28864573.

Mülleder M, Bluemlein K, Ralser M:
A High-Throughput Method for the Quantitative Determination of Free Amino Acids in Saccharomyces cerevisiae by Hydrophilic Interaction Chromatography-Tandem Mass Spectrometry.
Cold Spring Harb Protoc. 2017 Sep 1. PMID: 28864565.

2016

Mülleder M, Calvani E, Alam MT, Wang RK, Eckerstorfer F, Zelezniak A, Ralser M:
Functional Metabolomics Describes the Yeast Biosynthetic Regulome.
Cell 2016 Oct. 6. PMID: 27693354

Alam MT, Zelezniak A, Mülleder M, Shliaha P, Schwarz R, Capuano F, Vowinckel J, Radmaneshfar E, Krüger A, Calvani E, Michel S, Börno S, Christen S, Patil KR, Timmermann B, Lilley KS, Ralser M:
The metabolic background is a global player in Saccharomyces gene expression epistasis.
Nature Microbiology. 2016. Vol. 2, no. 1, 15030 (2016). PMID: 27572163

Campbell K, Vowinckel J, Ralser M:
Cell-to-cell heterogeneity emerges as consequence of metabolic cooperation in a synthetic yeast community.
Biotechnol J. 2016 Jun 17. PMID: 27312776

Watson E, Olin-Sandoval V, Hoy MJ, Li CH, Louisse T, Yao V, Mori A, Holdorf AD, Troyanskaya OG,  Ralser M, Walhout AJM:
Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans.
eLife. 2016;10.7554/eLife.17670. PMID: 27383050

Fabre B, Korona D, Groen A, Vowinckel J, Gatto L, Deery MJ, Ralser M, Russell S & Lilley KS:
Analysis of the Drosophila melanogaster proteome dynamics during the embryo early development by a combination of label-free proteomics approaches Proteomics.
2016 Mar 31. PMID: 27029218

Keller MA, Zylstra A, Castro C, Turchyn AV, Griffin JL, Ralser M:
Conditional iron and pH-dependent activity of a non-enzymatic glycolysis and pentose phosphate pathway.
Science Adv 2016.

Paglia G, Stocchero M, Cacciatore S, Lai S, Angel P, Alam MT, Keller M, Ralser M, Astarita G:
Unbiased Metabolomic Investigation of Alzheimer's Disease BrainPoints to Dysregulation of Mitochondrial Aspartate Metabolism.
J Proteome Res. 2016 Jan 12. PMID: 26717242.

Widder S, Allen RJ, Pfeiffer T, Curtis TP, Wiuf C, Sloan WT, Cordero OX, Brown SP, Momeni B, Shou W, Kettle H, Flint HJ, Haas AF, Laroche B, Kreft JU, Rainey PB, Freilich S, Schuster S, Milferstedt K, van der Meer JR, Groszkopf T, Huisman J, Free A, Picioreanu C, Quince C, Klapper I, Labarthe S, Smets BF, Wang H, Allison SD, Chong J, Lagomarsino MC, Croze OA, Hamelin J, Harmand J, Hoyle R, Hwa TT, Jin Q,  Johnson DR, de Lorenzo V, Mobilia M, Murphy B, Peaudecerf F, Prosser JI, Quinn RA, Ralser M, Smith AG,  Steyer JP, Swainston N, Tarnita CE, Trably E, Warren PB, Wilmes P, Soyer OS:
Challenges in microbial ecology: building predictive understanding of community function and Dynamics. ISME J. 2016 Mar 29. PMID: 27022995

2015

Campbell K, Vowinckel J, Keller MA, Ralser M:
Methionine metabolism alters oxidative stress resistance via the pentose phosphate pathway.
Antioxid Redox Signal 2015 Nov 23. PMID: 26596469

Campbell K, Vowinckel J, Mülleder M, Malmsheimer S, Lawrence N, Calvani E, Miller-Fleming L, Alam MT, Christen S, Keller MA, Ralser M:
Self-establishing communities enable cooperative metabolite Exchange in a eukaryote.
eLife 2015 Oct 26. PMID: 26499891

Piedrafita G, Keller MA, Ralser M:
Metabolic Remodeling in Times of Stress: Who Shoots Faster than His Shadow?
Molecular Cell 2015 Aug 20. PMID: 26295959

Jack CV; Cruz C, Hull RM, Keller MA, Ralser M, Houseley J:
Regulation of ribosomal DNA amplification by the TOR pathway.
Proc Natl Acad Sci USA 2015 Aug 4. PMID: 26195783

Vowinckel J, Hartl J, Butler R, Ralser M:
MitoLoc: A method for the simultaneous quantification of mitochondrial network morphology and membrane potential in single cells.
Mitochondrion. 2015 Sep;24:77-86. doi:10.1016/j.mito.2015.07.001. PubMed PMID: 26184437

Miller-Fleming L, Olin-Sandoval V, Campbell K, Ralser M:
Remaining Mysteries of Molecular Biology: The Role of Polyamines in the Cell.
J Mol Biol. 2015 Oct23;427(21):3389-406. doi: 10.1016/j.jmb.2015.06.020. Epub 2015 Jul 5. Review. PMID: 26156863

Michel S, Keller MA, Wamelink MM, Ralser M:
A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance.
BMC Genet. 2015 Feb 11;16:13. doi: 10.1186/s12863-015-0171-6. PubMed PMID: 25887987

Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM:
A roadmap for interpreting (13)C metabolite labeling patterns from cells.
Curr Opin Biotechnol. 2015Aug;34:189-201. doi: 10.1016/j.copbio.2015.02.003. Epub 2015 Feb 28. Review. PubMed PMID: 25731751

Watschinger K, Keller MA, McNeill E, Alam MT, Lai S, Sailer S, Rauch V, PatelJ, Hermetter A, Golderer G, Geley S, Werner-Felmayer G, Plumb RS, Astarita G,Ralser M, Channon KM, Werner ER:
Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome.
Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2431-6. doi: 10.1073/pnas.1414887112. Epub 2015 Feb9. PubMed PMID: 25675482

Jeffares DC, Rallis C, Rieux A, Speed D, Prevorovský M, Mourier T, Marsellach FX, Iqbal Z, Lau W, Cheng TM, Pracana R, Mülleder M, Lawson JL, Chessel A, Bala S, Hellenthal G, O'Fallon B, Keane T, Simpson JT, Bischof L, Tomiczek B, Bitton DA, Sideri T, Codlin S, Hellberg JE, van Trigt L, Jeffery L, Li JJ, Atkinson S, Thodberg M, Febrer M, McLay K, Drou N, Brown W, Hayles J, Carazo Salas RE, Ralser M, Maniatis N, Balding DJ, Balloux F, Durbin R, Bähler J:
The genomic andphenotypic diversity of Schizosaccharomyces pombe.
Nature Genet. 2015 Mar;47(3):235-41. doi: 10.1038/ng.3215. Epub 2015 Feb 9. PubMed PMID: 25665008

Frankl-Vilches C, Kuhl H, Werber M, Klages S, Kerick M, Bakker A, de Oliveira EH, Reusch C, Capuano F, Vowinckel J, Leitner S, Ralser M, Timmermann B, Gahr M:
Using the canary genome to decipher the evolution of hormone-sensitive generegulation in seasonal singing birds.
Genome Biol. 2015 Jan 29;16:19. doi:10.1186/s13059-014-0578-9. PubMed PMID: 25631560

Keller MA, Piedrafita G, Ralser M:
The widespread role of non-enzymaticreactions in cellular metabolism.
Curr Opin Biotechnol. 2015 Aug;34:153-61. doi: 10.1016/j.copbio.2014.12.020. Epub 2015 Jan 22. Review. PubMed PMID: 25617827

Timm KN, Hartl J, Keller MA, Hu DE, Kettunen MI, Rodrigues TB, Ralser M, Brindle KM:
Hyperpolarized [U-(2) H, U-(13) C]Glucose reports on glycolytic andpentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells.
Magn Reson Med. 2015 Dec;74(6):1543-7. doi: 10.1002/mrm.25561. Epub 2014Dec 17. PubMed PMID: 25522215

2014

Stincone A, Prigione A, Cramer T, Wamelink MM, Campbell K, Cheung E, Olin-Sandoval V, Grüning N, Krüger A, Tauqeer Alam M, Keller MA, Breitenbach M,Brindle KM, Rabinowitz JD, Ralser M:
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway.
Biological Reviews. 2014 Sep 22. doi: 10.1111/brv.12140. PubMed PMID: 25243985

Ralser M:
The RNA world and the origin of metabolic enzymes.
Biochem Soc Trans. 2014 Aug;42(4):985-8. doi: 10.1042/BST20140132. Review. PubMed PMID: 25109990

Keller MA, Zander U, Fuchs JE, Kreutz C, Watschinger K, Mueller T, Golderer G, Liedl KR, Ralser M, Kräutler B, Werner ER, Marquez JA:
A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase.
Nature Commun. 2014 Jul 22;5:4439. doi: 10.1038/ncomms5439. PubMed PMID: 25047030

Keller MA, Turchyn AV, Ralser M:
Non-enzymatic glycolysis and pentose phosphate pathway-like reactions in a plausible Archean ocean.
Mol Syst Biol. 2014 Apr 25;10:725. doi: 10.1002/msb.20145228. PubMed PMID: 24771084

Capuano F, Mülleder M, Kok R, Blom HJ, Ralser M:
Cytosine DNA methylation is found in Drosophila melanogaster but absent in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and other yeast species.
Anal Chem. 2014 Apr15;86(8):3697-702. doi: 10.1021/ac500447w. Epub 2014 Mar 25. PubMed PMID:24640988

Grüning NM, Du D, Keller MA, Luisi BF, Ralser M:
Inhibition of triosephosphate isomerase by phosphoenol pyruvate in the feedback-regulation of glycolysis.
Open Biol. 2014 Mar 5;4:130232. doi: 10.1098/rsob.130232. PubMed PMID: 24598263

Breitenbach M, Rinnerthaler M, Hartl J, Stincone A, Vowinckel J, Breitenbach-Koller H, Ralser M:
Mitochondria in ageing: there is metabolismbeyond the ROS.
FEMS Yeast Res. 2014 Feb;14(1):198-212. doi:10.1111/1567-1364.12134. Epub 2014 Jan 16. Review. PubMed PMID: 24373480

2013

Vowinckel J, Capuano F, Campbell K, Deery MJ, Lilley KS, Ralser M:
The beauty of being (label)-free: sample preparation methods for SWATH-MS and next-generation targeted proteomics. Version 2.
F1000Res. 2013 Dec 13 [revised 2014 Apr 7];2:272. doi: 10.12688/f1000research.2-272.v2. eCollection 2013. PubMed PMID: 24741437

2012

Mülleder M, Capuano F, Pir P, Christen S, Sauer U, Oliver SG, Ralser M:
A prototrophic deletion mutant collection for yeast metabolomics and systems biology.
Nature Biotechnology 2012 Dec;30(12):1176-8. doi: 10.1038/nbt.2442. PubMed PMID: 23222782

Bluemlein K, Glückmann M, Grüning NM, Feichtinger R, Krüger A, Wamelink M, Lehrach H, Tate S, Neureiter D, Kofler B, Ralser M:
Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis.
Oncotarget. 2012 Nov;3(11):1356-69. PubMed PMID: 23154538

Vowinckel J, Stahlberg S, Paulmann N, Bluemlein K, Grohmann M, Ralser M,Walther DJ:
Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling.
FEBS Lett. 2012 Nov2;586(21):3819-24. doi: 10.1016/j.febslet.2012.09.027. Epub 2012 Sep 26. PubMed PMID: 23022564

Ralser M, Kuhl H, Ralser M, Werber M, Lehrach H, Breitenbach M, Timmermann B:
The Saccharomyces cerevisiae W303-K6001 cross-platform genome sequence: insights into ancestry and physiology of a laboratory mutt.
Open Biol. 2012 Aug;2(8):120093. doi: 10.1098/rsob.120093. PubMed PMID: 22977733

Habermann K, Mirgorodskaya E, Gobom J, Lehmann V, Müller H, Blümlein K, DeeryMJ, Czogiel I, Erdmann C, Ralser M, von Kries JP, Lange BM:
Functional analysis of centrosomal kinase substrates in Drosophila melanogaster reveals a newfunction of the nuclear envelope component otefin in cell cycle progression.
Mol Cell Biol. 2012 Sep;32(17):3554-69. doi: 10.1128/MCB.00814-12. Epub 2012 Jul 2. PubMed PMID: 22751930

Ralser M, Michel S, Breitenbach M:
Sirtuins as regulators of the yeast metabolic network.
Front Pharmacol. 2012 Mar 8;3:32. doi:10.3389/fphar.2012.00032. eCollection 2012. PubMed PMID: 22408620

Breitenbach M, Laun P, Dickinson JR, Klocker A, Rinnerthaler M, Dawes IW,Aung-Htut MT, Breitenbach-Koller L, Caballero A, Nyström T, Büttner S, Eisenberg T, Madeo F, Ralser M:
The role of mitochondria in the aging processes of yeast.
Subcell Biochem. 2012;57:55-78. doi: 10.1007/978-94-007-2561-4_3. Review. PubMed PMID: 22094417. 

2011

Grüning NM, Ralser M:
Cancer: Sacrifice for survival.
Nature. 2011 Dec7;480(7376):190-1. doi: 10.1038/480190a. PubMed PMID: 22158241  

Grüning NM, Rinnerthaler M, Bluemlein K, Mülleder M, Wamelink MM, Lehrach H, Jakobs C, Breitenbach M, Ralser M:
Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells.
Cell Metabolism. 2011 Sep7;14(3):415-27. doi: 10.1016/j.cmet.2011.06.017. PubMed PMID: 21907146

Bluemlein K, Grüning NM, Feichtinger RG, Lehrach H, Kofler B, Ralser M:
No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis.
Oncotarget. 2011 May;2(5):393-400. PubMed PMID: 21789790

Prigione A, Lichtner B, Kuhl H, Struys EA, Wamelink M, Lehrach H, Ralser M,Timmermann B, Adjaye J:
Human induced pluripotent stem cells harbor homoplasmicand heteroplasmic mitochondrial DNA mutations while maintaining human embryonicstem cell-like metabolic reprogramming.
Stem Cells. 2011 Sep;29(9):1338-48. doi: 10.1002/stem.683. PMID: 21732474

Bluemlein K, Ralser M:
Monitoring protein expression in whole-cell extractsby targeted label- and standard-free LC-MS/MS.
Nature Protocols 2011 Jun;6(6):859-69. doi: 10.1038/nprot.2011.333. Epub 2011 May 26. PubMed PMID: 21637204 

Krüger A, Ralser M:
ATM is a redox sensor linking genome stability and carbon metabolism.
Sci Signal. 2011 Apr 5;4(167):pe17. doi: 10.1126/scisignal.2001959. PubMed PMID: 21467295 

Hallen L, Klein H, Stoschek C, Wehrmeyer S, Nonhoff U, Ralser M, Wilde J,Röhr C, Schweiger MR, Zatloukal K, Vingron M, Lehrach H, Konthur Z, Krobitsch S:
The KRAB-containing zinc-finger transcriptional regulator ZBRK1 activates SCA2gene transcription through direct interaction with its gene product, ataxin-2.
Hum Mol Genet. 2011 Jan 1;20(1):104-14. doi: 10.1093/hmg/ddq436. Epub 2010 Oct 6. PubMed PMID: 20926453

2010

Timmermann B, Jarolim S, Russmayer H, Kerick M, Michel S, Krüger A, Bluemlein K, Laun P, Grillari J, Lehrach H, Breitenbach M, Ralser M:
A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of randommutagenized yeast causes oxidant-resistance and premature aging.
Aging 2010 Aug;2(8):475-86. PubMed PMID: 20729566

Wamelink MM, Grüning NM, Jansen EE, Bluemlein K, Lehrach H, Jakobs C, Ralser M:
The difference between rare and exceptionally rare: molecular characterizationof ribose 5-phosphate isomerase deficiency.
J Mol Med. 2010 Sep;88(9):931-9. doi: 10.1007/s00109-010-0634-1. Epub 2010 May 25. PubMed PMID:20499043

2009 - 2005

Postma L, Lehrach H, Ralser M:
Surviving in the cold: yeast mutants withextended hibernating lifespan are oxidant sensitive.
Aging. 2009 Dec 4;1(11):957-60. PubMed PMID: 20157578 

Ralser M, Lehrach H:
Building a new bridge between metabolism, free radicals and longevity.
Aging. 2009 Sep 26;1(10):836-8. PubMed PMID: 20157554 

Grüning NM, Lehrach H, Ralser M:
Regulatory crosstalk of the metabolic network.
Trends Biochem Sci. 2010 Apr;35(4):220-7. doi:10.1016/j.tibs.2009.12.001. Epub 2010 Jan 7. Review. PubMed PMID: 20060301

Ralser M, Wamelink MM, Latkolik S, Jansen EE, Lehrach H, Jakobs C:
Metabolic reconfiguration precedes transcriptional regulation in the antioxidant response.
Nature Biotechnol. 2009 Jul;27(7):604-5. doi: 10.1038/nbt0709-604. PubMed PMID:19587661

Ralser M, Zeidler U, Lehrach H:
Interfering with glycolysis causes Sir2-dependent hyper-recombination of Saccharomyces cerevisiae plasmids.
PLoSOne. 2009;4(4):e5376. doi: 10.1371/journal.pone.0005376. Epub 2009 Apr 24. PubMedPMID: 19390637

Ralser M, Wamelink MM, Struys EA, Joppich C, Krobitsch S, Jakobs C, Lehrach H:
A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibit scell growth.
Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17807-11. doi:10.1073/pnas.0803090105. Epub 2008 Nov 11. PubMed PMID: 19004802

Ralser M, Benjamin IJ:
Reductive stress on life span extension in C. elegans.
BMC Res Notes. 2008 Jun 4;1:19. doi: 10.1186/1756-0500-1-19. PubMed PMID:18710529 

Ralser M, Nebel A, Kleindorp R, Krobitsch S, Lehrach H, Schreiber S, Reinhardt R, Timmermann B:
Sequencing and genotypic analysis of thetriosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans.
BMC Genet. 2008 May 29;9:38. doi: 10.1186/1471-2156-9-38. PubMed PMID: 18510744

Ralser M, Wamelink MM, Kowald A, Gerisch B, Heeren G, Struys EA, Klipp E, Jakobs C, Breitenbach M, Lehrach H, Krobitsch S:
Dynamic rerouting of thecarbohydrate flux is key to counteracting oxidative stress.
J Biol. 2007 Dec21;6(4):10. PubMed PMID: 18154684 

Nonhoff U, Ralser M, Welzel F, Piccini I, Balzereit D, Yaspo ML, Lehrach H, Krobitsch S:
Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.
Mol Biol Cell. 2007Apr;18(4):1385-96. Epub 2007 Feb 7. PubMed PMID: 17392519

Ralser M, Heeren G, Breitenbach M, Lehrach H, Krobitsch S:
Triose phosphate isomerase deficiency is caused by altered dimerization—not catalyticinactivity—of the mutant enzymes.
PLoS One. 2006 Dec 20;1:e30. PubMed PMID:17183658 

Ralser M, Querfurth R, Warnatz HJ, Lehrach H, Yaspo ML, Krobitsch S:
An efficient and economic enhancer mix for PCR.
Biochem Biophys Res Commun. 2006 Sep1;347(3):747-51. Epub 2006 Jul 5. PubMed PMID: 16842759 

Ralser M, Goehler H, Wanker EE, Lehrach H, Krobitsch S:
Generation of a yeast two-hybrid strain suitable for competitive protein binding analysis.
Biotechniques. 2005 Aug;39(2):165-6, 168. PubMed PMID: 16116786 

Ralser M, Nonhoff U, Albrecht M, Lengauer T, Wanker EE, Lehrach H, Krobitsch S:
Ataxin-2 and huntingtin interact with endophilin-A complexes to function inplastin-associated pathways.
Hum Mol Genet. 2005 Oct 1;14(19):2893-909. Epub 2005 Aug 22. PubMed PMID: 16115810

Ralser M, Albrecht M, Nonhoff U, Lengauer T, Lehrach H, Krobitsch S:
An integrative approach to gain insights into the cellular function of human ataxin-2.
J Mol Biol. 2005 Feb11;346(1):203-14. Epub 2004 Dec 10. PubMed PMID:15663938