Publikationen aus dem Forschungsschwerpunkt Regulation des UPS

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2016

  • Sotzny F, Schormann E, Kühlewindt I, Koch A, Brehm A, Goldbach-Mansky R, Gilling KE,
    Krüger E.
    TCF11/Nrf1-Mediated Induction of Proteasome Expression Prevents Cytotoxicity by Rotenone.
    Antioxid Redox Signal. 2016 Dec 1;25(16):870-885. Epub 2016 Nov 14.

  • Ebstein F, Keller M, Paschen A, Walden P, Seeger M, Bürger E, Krüger E, Schadendorf D, Kloetzel PM, Seifert U.
    Exposure to Melan-A/MART-126-35 tumor epitope specific CD8(+)T cells reveals immune escape by affecting the ubiquitin-proteasome system (UPS).
    Sci Rep. 2016 May 4;6:25208. doi: 10.1038/srep25208.
  • Brehm A, Liu Y, Sheikh A, Marrero B, Omoyinmi E, Zhou Q, Montealegre G, Biancotto A, Reinhardt A, de Jesus AA, Pelletier M, Tsai WL, Remmers EF, Kardava L, Hill S, Kim H, Lachmann HJ, Megarbane A, Chae JJ, Brady J, Castillo RD, Brown D, Casano AV, Gao L, Chapelle D, Huang Y, Stone D, Chen Y, Sotzny F, Lee CC, Kastner DL, Torrelo A, Zlotogorski A, Moir S, Gadina M, McCoy P, Wesley R, Rother KI, Hildebrand PW, Brogan P, Krüger E, Aksentijevich I, Goldbach-Mansky R.
    Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production.
    J Clin Invest. 2016 Feb;126(2):795. doi: 10.1172/JCI86020. Epub 2016 Feb 1.

  • Vangala JR, Sotzny F, Krüger E, Deshaies RJ, Radhakrishnan SK.
    Nrf1 can be processed and activated in a proteasome-independent manner.
    Curr Biol. 2016 Sep 26;26(18):R834-5. doi: 10.1016/j.cub.2016.08.008.
  • Feist E, Burmester GR, Krüger E.
    The proteasome - victim or culprit in autoimmunity.
    Clin Immunol. 2016 Nov;172:83-89. doi: 10.1016/j.clim.2016.07.018. Epub 2016 Jul 27.

2015

  • Schubert N, Dudeck J, Liu P, Karutz A, Speier S, Maurer M, Tuckermann J, Dudeck A.
    Mast cell promotion of T cell-driven antigen-induced arthritis despite being dispensable for antibody-induced arthritis in which T cells are bypassed.
    Arthritis Rheumatol. 2015 Apr; 67(4):903-13
  • Dudeck J, Ghouse SM, Lehmann CHK, Hoppe A, Schubert N, Nedospasov SA, Dudziak D, Dudeck A.
    Mast-Cell-Derived TNF Amplifies CD8+ Dendritic Cell Functionality and CD8+ T Cell Priming.
    Cell Rep. 2015 Oct 13, 13(2):399-411
  • Keller M, Ebstein F, Bürger E, Textoris-Taube K, Gorny X, Urban S, Zhao F, Dannenberg T, Sucker A, Keller C, Saveanu L, Krüger E, Rothkötter HJ, Dahlmann B, Henklein P, Voigt A, Kuckelkorn U, Paschen A, Kloetzel PM, Seifert U.
    The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35 -specific T-cell recognition.
    Eur J Immunol. 2015 Dec;45(12):3257-68. doi: 10.1002/eji.201445243. Epub 2015 Oct 19.
  • Brehm A, Liu Y, Sheikh A, Marrero B, Omoyinmi E, Zhou Q, Montealegre G, Biancotto A, Reinhardt A, Almeida de Jesus A, Pelletier M, Tsai WL, Remmers EF, Kardava L, Hill S, Kim H, Lachmann HJ, Megarbane A, Chae JJ, Brady J, Castillo RD, Brown D, Casano AV, Gao L, Chapelle D, Huang Y, Stone D, Chen Y, Sotzny F, Lee CC, Kastner DL, Torrelo A, Zlotogorski A, Moir S, Gadina M, McCoy P, Wesley R, Rother KI, Hildebrand PW, Brogan P, Krüger E, Aksentijevich I, Goldbach-Mansky R.
    Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production.
    J Clin Invest. 2015 Nov 2;125(11):4196-211. doi: 10.1172/JCI81260. Epub 2015 Oct 20.
  • Zhang X, Schulz R, Edmunds S, Krüger E, Markert E, Gaedcke J, Cormet-Boyaka E, Ghadimi M, Beissbarth T, Levine AJ, Moll UM, Dobbelstein M.
    MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP.
    Mol Cell. 2015 Jul 16;59(2):243-57. doi: 10.1016/j.molcel.2015.05.036. Epub 2015 Jul 2.
  • Brehm A, Krüger E.
    Dysfunction in protein clearance by the proteasome: impact on autoinflammatory diseases.
    Semin Immunopathol. 2015 Jul;37(4):323-33. doi: 10.1007/s00281-015-0486-4. Epub 2015 May 12.
  • Record J, Malinova D, Zenner HL, Plagnol V, Nowak K, Syed F, Bouma G, Curtis J, Gilmour K, Cale C, Hackett S, Charras G, Moulding D, Nejentsev S, Thrasher AJ, Burns SO.
    Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1.
    Blood. 2015 Sep 24;126(13):1527-35. doi: 10.1182/blood-2014-12-611012. Epub 2015 Jul 29.
  • Ongherth A, Pasch S, Wuertz CM, Nowak K, Kittana N, Weis CA, Jatho A, Vettel C, Tiburcy M, Toischer K, Hasenfuss G, Zimmermann WH, Wieland T, Lutz S.
    p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts.
    J Mol Cell Cardiol. 2015 Nov;88:39-54. doi: 10.1016/j.yjmcc.2015.09.009. Epub 2015 Sep 21

2014

  • Parsons CG and Gilling KE.
    Patch Clamp Combined with Voltage/Concentration Clamp to Determine the Kinetics and Voltage Dependency of N-Methyl-D-aspartate (NMDA) Receptor Open Channel Blockers.
    Methods Mol Biol. 2014; 1183:43-63. doi: 10.1007/978-1-4939-1096-0_3.
  • Jonigk D, Izykowski N, Maegel L, Schormann E, Ludewig B, Kreipe H, Hussein K.
    Tumour angiogenesis in Epstein-Barr virus-associated post-transplant smooth muscle tumours.
    Clin Sarcoma Res. 2014 Jan 7;4(1):1. doi: 10.1186/2045-3329-4-1.
  • Peschke K, Weitzmann A, Heger K, Behrendt R, Schubert N, Scholten J, Voehringer D, Hartmann K, Dudeck A, Schmidt-Supprian M, Roers A.
    IκB kinase 2 is essential for IgE-induced mast cell de novo cytokine production but not for degranulation.
    Cell Rep. 2014 Sep 11; 8(5):1300-7
  • King SJ, Nowak K, Suryavanshi N, Holt I, Shanahan CM, Ridley AJ.
    Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.
    Cytoskeleton (Hoboken). 2014 Jul;71(7):423-34. doi: 10.1002/cm.21182. Epub 2014 Jun 25.

2013

  • Ebstein F, Voigt A, Lange N, Warnatsch A, Schröter F, Prozorovski T, Kuckelkorn U, Aktas O, Seifert U, Kloetzel PM, Krüger E.
    Immunoproteasomes are important for proteostasis in immune responses.
    Cell. 2013 Feb 28; 152(5):935-7. doi: 10.1016/j.cell.2013.02.018. PubMed PMID: 23452842.
  • Voigt A, Rahnefeld A, Kloetzel PM, Krüger E.
    Cytokine-induced oxidative stress in cardiac inflammation and heart failure-how the ubiquitin proteasome system targets this vicious cycle.
    Front Physiol. 2013; 4:42. doi: 10.3389/fphys.2013.00042. Epub 2013 Mar 6. PubMed PMID: 23508734; PubMed Central PMCID: PMC3589765.
  • Warnatsch A, Bergann T, Krüger E.
    Oxidation matters: the ubiquitin proteasome system connects innate immune mechanisms with MHC class I antigen presentation.
    Mol Immunol. 2013 Sep; 55(2):106-9. doi: 10.1016/j.molimm.2012.10.007. Epub 2012 Nov 7.
  • Gilling KE, Oltmanns F, Behr J.
    Impaired maturation of serotonergic function in the dentate gyrus associated with epilepsy.
    Neurobiol Dis. 2013 Feb; 50:86-95. doi: 10.1016/j.nbd.2012.10.012. Epub 2012 Oct 13. PubMed PMID: 23072977.
  • Behrendt R, Schumann T, Gerbaulet A, Nguyen LA, Schubert N, Alexopoulou D, Berka U, Lienenklaus S, Peschke K, Gibbert K, Wittmann S, Lindemann D, Weiss S, Dahl A, Naumann R, Dittmer U, Kim B, Mueller W, Gramberg T, Roers A.
    Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response.
    Cell Rep. 2013 Aug 29; 4(4):689-96
  • Nothdurfter C, Tanasic S, Di Benedetto B, Uhr M, Wagner EM, Gilling KE, Parsons CG, Rein T, Holsboer F, Rupprecht R, Rammes G.
    Lipid raft integrity affects GABAA receptor, but not NMDA receptor modulation by psychopharmacological compounds.
    Int J Neuropsychopharmacol. 2013 Jul; 16(6):1361-71. doi: 10.1017/S146114571200140X. Epub 2012 Dec 10.
  • Jonigk D, Izykowski N, Maegel L, Schormann E, Maecker-Kolhoff B, Laenger F, Kreipe H, Hussein K.
    MicroRNA expression in Epstein-Barr virus-associated post-transplant smooth muscle tumours is related to leiomyomatous phenotype.
    Clin Sarcoma Res. 2013 Jul 6;3(1):9. doi: 10.1186/2045-3329-3-9.
  • Pilatz A1, Altinkilic B, Schormann E, Maegel L, Izykowski N, Becker J, Weidner W, Kreipe H, Jonigk D.
    Congenital phimosis in patients with and without lichen sclerosus: distinct expression patterns of tissue remodeling associated genes.
    J Urol. 2013 Jan;189(1):268-74. doi: 10.1016/j.juro.2012.09.010. Epub 2012 Nov 20.

2012

  • Krüger E and Kloetzel P-M.
    Immunoproteasomes at the interface of innate and adaptive immune responses: two faces of one enzyme.
    Curr Opin Immunol. 2012 Feb; 24(1):77-83. Epub 2012 Jan 31.
  • Ebstein F, Kloetzel PM, Krüger E, Seifert U.
    Emerging roles of immunoproteasomes beyond MHC class I antigen processing.
    Cell Mol Life Sci. 2012 Aug;69(15):2543-58. Epub 2012 Mar 2.

  • Gilling KE, Oltmanns F, Behr J.
    Impaired maturation of serotonergic function in the dentate gyrus associated with epilepsy.
    Neurobiol Dis. 2013 Feb;50:86-95. doi: 10.1016/j.nbd.2012.10.012. Epub 2012 Oct 13
  • Kuntzsch D, Bergann T, Dames P, Fromm A, Davis RA, Melzig MF, Schulzke JD.
    The plant-derived glucocorticoid receptor agonist Endiandrin A acts as co-stimulator of colonic epithelial sodium channels (ENaC) via SGK-1 and MAPKs.
    PLoS One. 2012;7(11):e49426. doi: 10.1371/journal.pone.0049426. Epub 2012 Nov 13.

  • Nothdurfter C, Tanasic S, Di Benedetto B, Uhr M, Wagner EM, Gilling KE, Parsons CG, Rein T, Holsboer F, Rupprecht R, Rammes G.
    Lipid raft integrity affects GABAA receptor, but not NMDA receptor modulation by psychopharmacological compounds.
    Int J Neuropsychopharmacol. 2012 Dec 10:1-11. [Epub ahead of print] PubMed PMID: 23217923.

2011

  • Koch A, Steffen J and Krüger E.
    TCF11 at the crossroads of oxidative stress and the ubiquitin proteasome system.
    Cell Cycle. 2011 Apr 15; 10(8):1200-7. Epub 2011 Apr 15.
  • Kriegenburg F, Poulsen EG, Koch A, Krüger E and Hartmann-Petersen R.
    Redox control of the ubiquitin-proteasome system: From molecular mechanisms to functional significance.
    Antioxid Redox Signal. 2011 Oct 15; 15(8):2265-99. Epub 2011 May 25.

  • Bergann T, Fromm A, Borden SA, Fromm M and Schulzke JD.
    Glucocorticoid receptor is indispensable for physiological responses to aldosterone in epithelial Na+ channel induction via the mineralocorticoid receptor in a human colonic cell line.
    Eur J Cell Biol. 2011 May: 90(5):432-9. Epub 2011 Feb 26
  • Opitz E, Koch A, Klingel K, Schmidt F, Prokop S, Rahnefeld A, Sauter M, Heppner FL, Völker U, Kandolf R, Kuckelkorn U, Stangl K, Krüger E, Kloetzel P-M and Voigt A.
    Impairment of immunoproteasome function by ß5i/LMP7 subunit deficiency results in severe enterovirus myocarditis.
    PLoS Pathog. 2011 Sep; 7(9):e1002233. Epub 2011 Sep 1.

  • Girmatsion Z, Biliczki P, Takac I, Schwerthelm C, Hohnloser SH and Ehrlich JR.
    N-terminal arginines modulate plasma-membrane localization of Kv7.1/KCNE1 channel complexes. PLoS One, 2011; 6(11):e26967.
  • Klopocki E, Lohan S, Brancati F, Koll R, Brehm A, Seemann P, Dathe K, Stricker S, Hecht J, Bosse K, Betz RC, Garaci FG, Dallapiccola B, Jain M, Muenke M, Ng VC, Chan W, Chan D and Mundlos S.
    Copy-number variations involving the IHH locus are associated with syndactyly and craniosynostosis.
    Am J Hum Genet. 2011 Jan 7; 88(1):70-5. Epub 2010 Dec 17.

2010

  • Koch A, Poirier F, Jacob R and Delacour D.
    Galectin-3, a novel centrosome-associated protein, required for epithelial morphogenesis.
    Mol Biol Cell. 2010 Jan 15;21(2):219-31. Epub 2009 Nov 18.
  • Seifert U, Bialy LP, Ebstein F, Bech-Otschir D, Voigt A, Schröter F, Prozorovski T, Lange N, Steffen J, Rieger M, Kuckelkorn U, Aktas O, Kloetzel P-M and Krüger E.
    Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress.
    Cell. 2010 Aug 20;142(4):613-24.

  • Girmatsion Z and Ehrlich JR.
    Implications of Remodeling in Atrial Fibrillation Therapy.
    European Cardiology. 2010; 6(3): 39-43.