
Publikationen des Labors Signaling mechanisms in brain development and disease
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2021
Parczyk, Jonas, Ruhnau, Jérôme, Pelz, Carsten, Schilling, Max, Wu, Hao, Piaskowski, Nicole Nadine, Eickholt, Britta, Kühn, Hartmut, Danker, Kerstin, Klein, Andreas (2021)
Dichloroacetate and PX-478 exhibit strong synergistic effects in a various number of cancer cell lines.
BMC Cancer. 2021;21( 1):481
Schiweck, Juliane, Murk, Kai, Ledderose, Julia, Münster-Wandowski, Agnieszka, Ornaghi, Marta, Vida, Imre, Eickholt, Britta J. (2021)
Drebrin controls scar formation and astrocyte reactivity upon traumatic brain injury by regulating membrane trafficking.
Nat Commun. 2021;12( 1):1490
Klemz, Alexander, Kreis, Patricia, Eickholt, Britta J, Gerevich, Zoltan (2021)
The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex.
Sci Rep. 2021;11( 1):8662
2020
Fuchs, Joachim, Eickholt, Britta J, Leondaritis, George (2020)
Harnessing PTEN's Growth Potential in Neuronal Development and Disease.
Neurosci Insights. 2020;15:2633105520959056
Zolnik, Timothy A, Ledderose, Julia, Toumazou, Maria, Trimbuch, Thorsten, Oram, Tess, Rosenmund, Christian, Eickholt, Britta J, Sachdev, Robert N S, Larkum, Matthew E. (2020)
Layer 6b Is Driven by Intracortical Long-Range Projection Neurons.
Cell Rep. 2020;30( 10):3492-505
Nieuwenhuis, Bart, Barber, Amanda C, Evans, Rachel S, Pearson, Craig S, Fuchs, Joachim, MacQueen, Amy R, van Erp, Susan, Haenzi, Barbara, Hulshof, Lianne A, Osborne, Andrew, Conceicao, Raquel, Khatib, Tasneem Z, Deshpande, Sarita S, Cave, Joshua, Ffrench-Constant, Charles, Smith, Patrice D, Okkenhaug, Klaus, Eickholt, Britta J, Martin, Keith R, Fawcett, James W, Eva, Richard (2020)
PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS.
Embo Mol Med. 2020;12( 8):e11674
Ruhnau, Jérôme, Parczyk, Jonas, Danker, Kerstin, Eickholt, Britta, Klein, Andreas (2020)
Synergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to screen for synergism.
BMC Cancer. 2020;20( 1):61
2019
Brosig A, Fuchs J, Ipek F, Kroon C, Schrötter S, Vadhvani M, Polyzou A, Ledderose J, van Diepen M, Holzhütter HG, Trimbuch T, Gimber N, Schmoranzer J, Lieberam I, Rosenmund C, Spahn C, Scheerer P, Szczepek M, Leondaritis G, Eickholt BJ (2019)
The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches.
Cell Rep. 29(7):2028-2040.e8. PMID: 31722215
Rademacher S, Eickholt BJ (2019) Review
PTEN in Autism and Neurodevelopmental Disorders.
Cold Spring Harb Perspect Med. 9(11). pii: a036780. PMID: 31427284
Ebner C, Ledderose J, Zolnik TA, Dominiak SE, Turko P, Papoutsi A, Poirazi P, Eickholt BJ, Vida I, Larkum ME, Sachdev RNS (2019)
Optically Induced Calcium-Dependent Gene Activation and Labeling of Active Neurons Using CaMPARI and Cal-Light.
Front Synaptic Neurosci. 11:16. PMID: 31178713
Jochner MCE, An J, Lättig-Tünnemann G, Kirchner M, Dagane A, Dittmar G, Dirnagl U, Eickholt BJ, Harms C (2019)
Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress.
Sci Rep. 2019 9(1):3183. PMID: 30816308
Kreis P, Gallrein C, Rojas-Puente E, Mack TGA, Kroon C, Dinkel V, Willmes C, Murk K, Tom-Dieck S, Schuman EM, Kirstein J, Eickholt BJ (2019)
ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.
Nat Commun. 10(1):486. PMID:30700723
2018
Panayotis N, Sheinin A, Dagan SY, Tsoory MM, Rother F, Vadhvani M, Meshcheriakova A, Koley S, Marvaldi L, Song DA, Reuveny E, Eickholt BJ, Hartmann E, Bader M, Michaelevski I, Fainzilber M (2018)
Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1.
Cell Rep. 25(11):3169-3179.e7. PMID: 30540948
Moeyaert B, Holt G, Madangopal R, Perez-Alvarez A, Fearey BC, Trojanowski NF, Ledderose J, Zolnik TA, Das A, Patel D, Brown TA, Sachdev RNS, Eickholt BJ, Larkum ME, Turrigiano GG, Dana H, Gee CE, Oertner TG, Hope BT, Schreiter ER (2018)
Improved methods for marking active neuron populations.
Nat Commun. 9(1):4440. PMID: 30361563
Schiweck J, Eickholt BJ, Murk K (2018)
Important Shapeshifter: Mechanisms Allowing Astrocytes to Respond to the Changing Nervous System During Development, Injury and Disease.
Front Cell Neurosci. 12:261. PMID: 30186118
Gao M, Maraspini R, Beutel O, Zehtabian A, Eickholt B, Honigmann A, Ewers H (2018)
Expansion Stimulated Emission Depletion Microscopy (ExSTED).
ACS Nano. 12(5):4178-4185. PMID: 29672025
Pelz C, Häckel S, Semini G, Schrötter S, Bintig W, Stricker S, Mrawietz G, Klein A, Lucka L, Shmanai V, Eickholt B, Hildmann A, Danker K (2018)
Inositol-C2-PAF acts as a biological Response modifier and antagonizes cancer-relevant processe in mammary carcinoma cells.
Cell Onocol (Dordr). 41(5):505-516. PMID: 30047091
Kath C, Goni-Oliver P, Müller R, Schultz C, Haucke V, Eickholt B, Schmoranzer J (2018)
PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules.
PLoS One. 4;13(4):e0193257.PMID: 29617365
2017
Willmes CG, Mack TG, Ledderose J, Schmitz D, Wozny C, Eickholt BJ (2017)
Investigation of hippocampal synaptic transmission and plasticity in mice deficient in the actin-binding protein Drebrin.
Sci Rep 7:42652. PMID:28198431
2016
Sampathkumar C, Wu YJ, Vadhvani M, Trimbuch T, Eickholt B, Rosenmund C (2016)
Loss of MeCP2 disrupts cell autonomous and autocrine BDNF signaling in mouse glutamatergic neurons.
Elife 5, e19374. PMID: 27782879
Schrötter S, Leondaritis G, Eickholt BJ. (2016)
Capillary isoelectric focusing of Akt isoforms identifies highly dynamic phosphorylation in neuronal cells and brain tissue.
J Biol Chem. 6, 291 (19):10239-51. PMID: 26945062
Grauel MK, Maglione M, Reddy-Alla S, Willmes CG, Brockmann MM, Trimbuch T, Rosenmund T, Pangalos M, Vardar G, Stumpf A, Walter AM, Rost BR, Eickholt BJ, Haucke V, Schmitz D, Sigrist SJ, Rosenmund C (2016)
RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.
Proc Natl Acad Sci U S A 113:11615-11620. PMID: 27671655
Adolf A, Leondaritis G, Rohrbeck A, Eickholt BJ, Just I, Ahnert-Hilger G, Höltje M. (2016)
The intermediate filament protein vimentin is essential for axonotrophic effects of Clostridium botulinum C3 exoenzyme.
J Neurochem. Oct;139(2):234-244. PMID:27419376
2015
Spinelli L, Black FM, Berg JN, Eickholt BJ, Leslie NR. (2015)
Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes.
J Med Genet. 52(2):128-34. PMID: 25527629
An W, Jackson RE, Hunter P, Gögel S, van Diepen M, Liu K, Meyer MP, Eickholt BJ. (2015)
Engineering FKBP-Based Destabilizing Domains to Build Sophisticated Protein Regulation Systems.
PLoS One. Dec 30;10(12). PMID: 26717575
2013
Kreis P, Hendricusdottir R, Kay L, Papageorgiou IE, van Diepen M, Mack T, Ryves J, Harwood A, Leslie NR, Kann O, Parsons M, Eickholt BJ. (2013).
Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN.
PLoS One. 2013 5;8(8). PMID: 23940795
Berglund FM, Weerasinghe NR, Davidson L, Lim JC, Eickholt BJ, Leslie NR. (2013).
Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1.
Oncogene. 12;32(37):4417-26. PMID: 23085752
2011
Kay, L., Humphreys, L., Eickholt, B.J. and Burrone, J. (2011).
Neuronal activity drives matching of pre- and post-synaptic function during synapse maturation.
Nat Neurosci 14, 688-90. PMID: 21532580
2005 - 2009
2009
van Diepen, M. T., Parsons, M., Downes, C. P., Leslie, N. R., Hindges, R. and Eickholt, B. J. (2009).
MyosinV controls PTEN function and neuronal cell size.
Nat Cell Biol 11, 1191-6. PMID: 19767745#
2008
Cosker, K. E., Shadan, S., van Diepen, M., Morgan, C., Li, M., Allen-Baume, V., Hobbs, C., Doherty, P., Cockcroft, S. and Eickholt, B. J. (2008).
Regulation of PI3K signalling by the phosphatidylinositol transfer protein PITPalpha during axonal extension in hippocampal Neurons
J Cell Sci 121, 796-803. PMID: 18285448
2007
Eickholt, B. J., Ahmed, A. I., Davies, M., Papakonstanti, E. A., Pearce, W., Starkey, M. L., Bilancio, A., Need, A. C., Smith, A. J., Hall, S. M. et al. (2007).
Control of Axonal Growth and Regeneration of Sensory Neurons by the p110delta PI 3-Kinase.
PLoS ONE 2, e869. PMID: 17846664
2006
Chadborn, N. H., Ahmed, A. I., Holt, M. R., Prinjha, R., Dunn, G. A., Jones, G. E. and Eickholt, B. J. (2006).
PTEN couples Sema3A signalling to growth cone collapse.
J Cell Sci 119, 951-957. PMID:16495486
Cole, A. R., Causeret, F., Yaeirgi, G., Hastie, C. J., McLauchlan, H., McManus, E. J., Hernandez, F., Eickholt, B. J., Nikolic, M. and Sutherland, C. (2006).
Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo.
J Biol Chem. PMID: 16611631
2005
Osborne, N. J., Begbie, J., Chilton, J. K., Schmidt, H. and Eickholt, B. J. (2005).
Semaphorin/neuropilin signaling influences the positioning of migratory neural crest cells within the hindbrain region of the chick.
Dev Dyn 232, 939-49. PMID: 15729704
Reviews
Mack TG, Kreis P, Eickholt BJ. (2016)
Defective actin dynamics in dendritic spines: cause or consequence of age-induced cognitive decline?
Biol Chem. 2016 Mar;397(3):223-9. PMID:26447486
Leondaritis G, Eickholt BJ. (2015)
Short Lives with Long-Lasting Effects: Filopodia Protrusions in Neuronal Branching Morphogenesis.
PLoS Biol. Sep 3;13(9):e1002241. PMID:26334727
Kreis P, Leondaritis G, Lieberam I, Eickholt BJ. (2014).
Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders.
Front Mol Neurosci. 1;7:23. PMID: 24744697
Waite K, Eickholt BJ (2010).
The neurodevelopmental implications of PI3K signaling.
Curr Top Microbiol Immunol 346: 245-265. PMID: 20582530
Jackson R. E. and Eickholt, B. J. (2009).
Semaphorin Signalling.
Current Biology. PMID: 19602408
Eickholt, B. J. (2008).
Functional diversity and mechanisms of action of the semaphorins.
Development 135, 2689-94. PMID: 18660466
van Diepen, M. T. and Eickholt, B. J. (2008).
Function of PTEN during the formation and maintenance of neuronal circuits in the brain.
Dev Neurosci 30, 59-64. PMID: 18075255
Ahmed, A. and Eickholt, B. J. (2008).
Intracellular kinases in semaphorin signaling.
Adv Exp Med Biol 600, 24-37. PMID: 17607944
Cosker, K. E. and Eickholt, B. J. (2007).
Phosphoinositide 3-kinase signalling events controlling axonal morphogenesis.
Biochem Soc Trans 35, 207-10. PMID: 17371239