Publikationen des Labors Signaling mechanisms in brain development and disease

Parczyk, Jonas, Ruhnau, Jérôme, Pelz, Carsten, Schilling, Max, Wu, Hao, Piaskowski, Nicole Nadine, Eickholt, Britta, Kühn, Hartmut, Danker, Kerstin, Klein, Andreas (2021)
Dichloroacetate and PX-478 exhibit strong synergistic effects in a various number of cancer cell lines.
BMC Cancer. 2021;21( 1):481

Schiweck, Juliane, Murk, Kai, Ledderose, Julia, Münster-Wandowski, Agnieszka, Ornaghi, Marta, Vida, Imre, Eickholt, Britta J. (2021)
Drebrin controls scar formation and astrocyte reactivity upon traumatic brain injury by regulating membrane trafficking.
Nat Commun. 2021;12( 1):1490

Klemz, Alexander, Kreis, Patricia, Eickholt, Britta J, Gerevich, Zoltan (2021)
The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex.
Sci Rep. 2021;11( 1):8662

Fuchs, Joachim, Eickholt, Britta J, Leondaritis, George (2020)
Harnessing PTEN's Growth Potential in Neuronal Development and Disease.
Neurosci Insights. 2020;15:2633105520959056

Zolnik, Timothy A, Ledderose, Julia, Toumazou, Maria, Trimbuch, Thorsten, Oram, Tess, Rosenmund, Christian, Eickholt, Britta J, Sachdev, Robert N S, Larkum, Matthew E. (2020)
Layer 6b Is Driven by Intracortical Long-Range Projection Neurons.
Cell Rep. 2020;30( 10):3492-505

Nieuwenhuis, Bart, Barber, Amanda C, Evans, Rachel S, Pearson, Craig S, Fuchs, Joachim, MacQueen, Amy R, van Erp, Susan, Haenzi, Barbara, Hulshof, Lianne A, Osborne, Andrew, Conceicao, Raquel, Khatib, Tasneem Z, Deshpande, Sarita S, Cave, Joshua, Ffrench-Constant, Charles, Smith, Patrice D, Okkenhaug, Klaus, Eickholt, Britta J, Martin, Keith R, Fawcett, James W, Eva, Richard (2020)
PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS.
Embo Mol Med. 2020;12( 8):e11674

Ruhnau, Jérôme, Parczyk, Jonas, Danker, Kerstin, Eickholt, Britta, Klein, Andreas (2020)
Synergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to screen for synergism.
BMC Cancer. 2020;20( 1):61

Brosig A, Fuchs J, Ipek F, Kroon C, Schrötter S, Vadhvani M, Polyzou A, Ledderose J, van Diepen M, Holzhütter HG, Trimbuch T, Gimber N, Schmoranzer J, Lieberam I, Rosenmund C, Spahn C, Scheerer P, Szczepek M, Leondaritis G, Eickholt BJ (2019) 
The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches.
Cell Rep. 29(7):2028-2040.e8. PMID: 31722215

Rademacher S, Eickholt BJ (2019) Review 
PTEN in Autism and Neurodevelopmental Disorders.
Cold Spring Harb Perspect Med. 9(11). pii: a036780. PMID: 31427284

Ebner C, Ledderose J, Zolnik TA, Dominiak SE, Turko P, Papoutsi A, Poirazi P, Eickholt BJ, Vida I, Larkum ME, Sachdev RNS (2019) 
Optically Induced Calcium-Dependent Gene Activation and Labeling of Active Neurons Using CaMPARI and Cal-Light.
Front Synaptic Neurosci. 11:16. PMID: 31178713

Jochner MCE, An J, Lättig-Tünnemann G, Kirchner M, Dagane A, Dittmar G, Dirnagl U, Eickholt BJ, Harms C (2019) 
Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress.
Sci Rep. 2019 9(1):3183. PMID: 30816308

Kreis P, Gallrein C, Rojas-Puente E, Mack TGA, Kroon C, Dinkel V, Willmes C, Murk K, Tom-Dieck S, Schuman EM, Kirstein J, Eickholt BJ (2019) 
ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.
Nat Commun. 10(1):486. PMID:30700723

Panayotis N, Sheinin A, Dagan SY, Tsoory MM, Rother F, Vadhvani M, Meshcheriakova A, Koley S, Marvaldi L, Song DA, Reuveny E, Eickholt BJ, Hartmann E, Bader M, Michaelevski I, Fainzilber M (2018) 
Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1.
Cell Rep. 25(11):3169-3179.e7. PMID: 30540948

Moeyaert B, Holt G, Madangopal R, Perez-Alvarez A, Fearey BC, Trojanowski NF, Ledderose J, Zolnik TA, Das A, Patel D, Brown TA, Sachdev RNS, Eickholt BJ, Larkum ME, Turrigiano GG, Dana H, Gee CE, Oertner TG, Hope BT, Schreiter ER (2018) 
Improved methods for marking active neuron populations.
Nat Commun. 9(1):4440. PMID: 30361563

Schiweck J, Eickholt BJ, Murk K (2018) 
Important Shapeshifter: Mechanisms Allowing Astrocytes to Respond to the Changing Nervous System During Development, Injury and Disease.
Front Cell Neurosci. 12:261. PMID: 30186118

Gao M, Maraspini R, Beutel O, Zehtabian A, Eickholt B, Honigmann A, Ewers H (2018) 
Expansion Stimulated Emission Depletion Microscopy (ExSTED).
ACS Nano. 12(5):4178-4185. PMID: 29672025

Pelz C, Häckel S, Semini G, Schrötter S, Bintig W, Stricker S, Mrawietz G, Klein A, Lucka L, Shmanai V, Eickholt B, Hildmann A, Danker K (2018) 
Inositol-C2-PAF acts as a biological Response modifier and antagonizes cancer-relevant processe in mammary carcinoma cells.
Cell Onocol (Dordr). 41(5):505-516. PMID: 30047091

Kath C, Goni-Oliver P, Müller R, Schultz C, Haucke V, Eickholt B, Schmoranzer J (2018)
PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules.
PLoS One. 4;13(4):e0193257.PMID: 29617365

Willmes CG, Mack TG, Ledderose J, Schmitz D, Wozny C, Eickholt BJ (2017)
Investigation of hippocampal synaptic transmission and plasticity in mice deficient in the actin-binding protein Drebrin.
Sci Rep 7:42652. PMID:28198431

Sampathkumar C, Wu YJ, Vadhvani M, Trimbuch T, Eickholt B, Rosenmund C (2016)
Loss of MeCP2 disrupts cell autonomous and autocrine BDNF signaling in mouse glutamatergic neurons.
Elife 5, e19374. PMID: 27782879

Schrötter S, Leondaritis G, Eickholt BJ. (2016)
Capillary isoelectric focusing of Akt isoforms identifies highly dynamic phosphorylation in neuronal cells and brain tissue.
J Biol Chem. 6, 291 (19):10239-51. PMID: 26945062

Grauel MK, Maglione M, Reddy-Alla S, Willmes CG, Brockmann MM, Trimbuch T, Rosenmund T, Pangalos M, Vardar G, Stumpf A, Walter AM, Rost BR, Eickholt BJ, Haucke V, Schmitz D, Sigrist SJ, Rosenmund C (2016)
RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.
Proc Natl Acad Sci U S A 113:11615-11620. PMID: 27671655

Adolf A, Leondaritis G, Rohrbeck A, Eickholt BJ, Just I, Ahnert-Hilger G, Höltje M. (2016)
The intermediate filament protein vimentin is essential for axonotrophic effects of Clostridium botulinum C3 exoenzyme.
J Neurochem. Oct;139(2):234-244. PMID:27419376

Spinelli L, Black FM, Berg JN, Eickholt BJ, Leslie NR. (2015)
Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes.
J Med Genet. 52(2):128-34. PMID: 25527629

An W, Jackson RE, Hunter P, Gögel S, van Diepen M, Liu K, Meyer MP, Eickholt BJ. (2015)
Engineering FKBP-Based Destabilizing Domains to Build Sophisticated Protein Regulation Systems.
PLoS One. Dec 30;10(12). PMID: 26717575

Kreis P, Hendricusdottir R, Kay L, Papageorgiou IE, van Diepen M, Mack T, Ryves J, Harwood A, Leslie NR, Kann O, Parsons M, Eickholt BJ. (2013).
Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN.
PLoS One. 2013 5;8(8). PMID: 23940795

Berglund FM, Weerasinghe NR, Davidson L, Lim JC, Eickholt BJ, Leslie NR. (2013).
Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1.
Oncogene. 12;32(37):4417-26. PMID: 23085752

Kay, L., Humphreys, L., Eickholt, B.J. and Burrone, J. (2011).
Neuronal activity drives matching of pre- and post-synaptic function during synapse maturation.
Nat Neurosci 14, 688-90. PMID: 21532580 

2009

van Diepen, M. T., Parsons, M., Downes, C. P., Leslie, N. R., Hindges, R. and Eickholt, B. J. (2009).
MyosinV controls PTEN function and neuronal cell size.
Nat Cell Biol 11, 1191-6. PMID: 19767745#

2008

Cosker, K. E., Shadan, S., van Diepen, M., Morgan, C., Li, M., Allen-Baume, V., Hobbs, C., Doherty, P., Cockcroft, S. and Eickholt, B. J. (2008).
Regulation of PI3K signalling by the phosphatidylinositol transfer protein PITPalpha during axonal extension in hippocampal Neurons
J Cell Sci 121, 796-803. PMID: 18285448

2007 

Eickholt, B. J., Ahmed, A. I., Davies, M., Papakonstanti, E. A., Pearce, W., Starkey, M. L., Bilancio, A., Need, A. C., Smith, A. J., Hall, S. M. et al. (2007).
Control of Axonal Growth and Regeneration of Sensory Neurons by the p110delta PI 3-Kinase.
PLoS ONE 2, e869. PMID: 17846664

2006 

Chadborn, N. H., Ahmed, A. I., Holt, M. R., Prinjha, R., Dunn, G. A., Jones, G. E. and Eickholt, B. J. (2006).
PTEN couples Sema3A signalling to growth cone collapse.
J Cell Sci 119, 951-957. PMID:16495486

Cole, A. R., Causeret, F., Yaeirgi, G., Hastie, C. J., McLauchlan, H., McManus, E. J., Hernandez, F., Eickholt, B. J., Nikolic, M. and Sutherland, C. (2006).
Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo.
J Biol Chem. PMID: 16611631

2005

Osborne, N. J., Begbie, J., Chilton, J. K., Schmidt, H. and Eickholt, B. J. (2005).
Semaphorin/neuropilin signaling influences the positioning of migratory neural crest cells within the hindbrain region of the chick.
Dev Dyn 232, 939-49. PMID: 15729704 

Mack TG, Kreis P, Eickholt BJ. (2016)
Defective actin dynamics in dendritic spines: cause or consequence of age-induced cognitive decline?
Biol Chem. 2016 Mar;397(3):223-9. PMID:26447486

Leondaritis G, Eickholt BJ. (2015)
Short Lives with Long-Lasting Effects: Filopodia Protrusions in Neuronal Branching Morphogenesis.
PLoS Biol. Sep 3;13(9):e1002241. PMID:26334727

Kreis P, Leondaritis G, Lieberam I, Eickholt BJ. (2014).
Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders.
Front Mol Neurosci. 1;7:23. PMID: 24744697

Eickholt, B. J. (2008).
Functional diversity and mechanisms of action of the semaphorins.
Development 135, 2689-94. PMID: 18660466

van Diepen, M. T. and Eickholt, B. J. (2008).
Function of PTEN during the formation and maintenance of neuronal circuits in the brain.
Dev Neurosci 30, 59-64. PMID: 18075255

Ahmed, A. and Eickholt, B. J. (2008).
Intracellular kinases in semaphorin signaling.
Adv Exp Med Biol 600, 24-37. PMID: 17607944

Cosker, K. E. and Eickholt, B. J. (2007).
Phosphoinositide 3-kinase signalling events controlling axonal morphogenesis.
Biochem Soc Trans 35, 207-10. PMID: 17371239